Why would rederivation be used?

Why would rederivation be used?

• A. To obtain an animal with a certain mutation
• B. To obtain an animal with a particular phenotype
• C. To obtain an animal with no infectious disease
• D. To obtain an animal with maximum genetic diversity

Answer: (C)

Rederivation is used to produce a clean, disease-free starting point for a line of animals. By transferring embryos into pathogen-free surrogate dams or performing cesarean rederivation, you remove pathogens that may be carried by the dam or present in the original facility, resulting in offspring with no infectious disease. The goal is to create animals that are free of infectious agents so they can be bred and used in experiments without introducing infections or confounding results. This is different from methods aimed at creating a specific mutation, selecting a particular phenotype, or increasing genetic diversity, which involve different breeding or genetic approaches rather than removing infectious agents.

Rederivation is used to produce a clean, disease-free starting point for a line of animals. By transferring embryos into pathogen-free surrogate dams or performing cesarean rederivation, you remove pathogens that may be carried by the dam or present in the original facility, resulting in offspring with no infectious disease. The goal is to create animals that are free of infectious agents so they can be bred and used in experiments without introducing infections or confounding results. This is different from methods aimed at creating a specific mutation, selecting a particular phenotype, or increasing genetic diversity, which involve different breeding or genetic approaches rather than removing infectious agents.